Rexulti: A Comprehensive Guide to Depression Treatment

rexulti for depression blog

Depression is a common mental health disorder that can impact anyone at any time. rexulti is a medication that is effective in the treatment of depression. In this comprehensive guide, we will discuss everything you need to know about rexulti for depression. We will cover how rexulti works, the potential side effects, and how to get started on rexulti therapy.

What Is Rexulti?  rexulti explanation

Rexulti (brexpiprazole) is an antipsychotic medication. It works by altering the levels of certain chemicals in the brain. Rexulti is used to treat major depressive disorder in adults.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

How Is It Useful For Depression? rexulti cures depression

  • Rexulti (brexpiprazole) is an antipsychotic medication that works by affecting chemicals in the brain. It is used to treat the major depressive disorder in adults.
  • It is important to note that rexulti is not a cure for depression, but rather it helps to reduce the symptoms. For some people, these symptoms may go away completely after taking rexulti for some time.
  • There are many different types of depression, each with its own set of symptoms. rexulti (brexpiprazole) is a medication that can help manage the symptoms of depression. rexulti works by affecting the levels of serotonin and dopamine in the brain. These are two neurotransmitters that play a role in mood and emotions.
  • By increasing the levels of these neurotransmitters, rexulti can help improve mood and reduce feelings of sadness or worthlessness. rexulti can also help to reduce anxiety, insomnia, and fatigue. In some cases, rexulti may also help to improve concentration and energy levels.

Therefore, rexulti is a medication that can help with the management of depression by improving mood and reducing symptoms

Who Should Use Rexulti? 

Rexulti should be used when other forms of treatment have failed. It can be used in combination with other forms of treatment, such as therapy or medication. Rexulti is not for everyone, and it is important to speak with a doctor before starting any new form of treatment. Rexulti for depression is applicable fro those  18 years or above

  • who are 18 years or older
  • have antidepressant-resistant depression
  • had no success with other medications
  • do not have a history of mania
  • have no liver problems
  • do not have a history of tardive dyskinesia

From the above bulletins, we can conclude that the specific drug is suitable for those people who suffer from depression and have not responded to other medications. Also, people with a history of mania or tardive dyskinesia should not take rexulti. Those who have liver problems also cannot use this drug to cure their depression.

So if you are an adult suffering from antidepressant-resistant depression, rexulti may be the right medication for you! Be sure to speak with your doctor about whether rexulti is the best option for your unique situation.

Please speak with your doctor first about whether Rexulti is right for you.

Who Should Not Use Rexulti?

The below-explained type of people would contraindicate the use of rexulti:

Hypersensitive People

There are a few reasons why hypersensitive people should not use rexulti for depression. First, rexulti can increase sensitivity to stimuli. This means that things that wouldn’t normally bother you could end up becoming overwhelming.

Additionally, rexulti can also cause problems with focus and concentration. For hypersensitive people who already have difficulty dealing with sensory input, this can be a major problem.

Finally, rexulti may also intensify emotions. So if you’re already feeling down, rexulti could make those feelings even worse. Overall, it’s just not worth the risk for hypersensitive people to take rexulti for depression.

Pregnant And Nursing Women  depression during pregnancy

There are a few reasons why rexulti may not be ideal for pregnant women who suffer from depression. First, the drug has not been extensively studied in pregnant women, so there is limited data on its safety.

Additionally, rexulti can pass into breast milk, so it could potentially harm a nursing infant. Finally, rexulti may cause some side effects that could be harmful to a developing fetus, such as weight gain and low blood sugar levels. Therefore, pregnant women must consult with their doctor before taking rexulti for depression.

Nursing women should also not use rexulti for depression because it can pass into breast milk and may harm a nursing baby. The most common side effects of rexulti include weight gain, headache, dizziness, feeling tired, constipation, nausea, and vomiting. If you experience any of these side effects while taking rexulti, be sure to contact your healthcare provider immediately.

Children And Adolescents Under 18 Years Old

There are a few key reasons why rexulti should not be used for treating depression in children and adolescents. First, the safety and efficacy of rexulti have not been established in this age group.

Second, rexulti can cause serious side effects, including weight gain, increases in blood sugar levels, and changes in cholesterol levels. Third, rexulti may interact with other medications that children and adolescents may be taking for other conditions.

Finally, rexulti is a relatively new medication, and its long-term effects are not yet known. For all of these reasons, it is generally recommended that children and adolescents not use rexulti for the treatment of depression.

Elderly Patients

Elderly patients should not use rexulti for depression because it can worsen their condition. The medication increases the levels of serotonin and norepinephrine in the brain, which can lead to an increase in anxiety and agitation.

Additionally, rexulti can cause dizziness, drowsiness, and confusion, which can be dangerous for elderly patients. Finally, rexulti is a new medication and has not been extensively studied in elderly populations, so the risks are not fully known.

Patients With Other Disorders

Rexulti can lower the seizure threshold, which means that it can increase the risk of seizures in patients with a history of seizures or manic episodes. Second, Rexulti can cause mania in patients with bipolar disorder. And finally, Rexulti can interact with other medications that are used to treat bipolar disorder, which can lead to serious side effects.

Rexulti may not be the best treatment option for those with a history of these conditions. As always, it is important to speak to a healthcare professional before starting any new medication to make sure it is the right fit for you.

How Is Rexulti Taken?  how to take rexulti

Rexulti is taken orally, usually once daily. The recommended starting dose is 0.25 mg/kg, which can be increased to a maximum of 0.50 mg/kg if needed and well tolerated. For patients weighing more than 60 kg, the recommended starting dose is 15 mg per day.

Rexulti should be taken with or without food. If you miss a dose of rexulti, take it as soon as you remember unless it’s almost time for your next scheduled dose. In that case, skip the missed rexulti dose and continue on your regular dosing schedule. Do not take two doses of results at the same time to make up for a missed one.

Further, rexulti may interact with other medications (such as lithium, valproate, or antipsychotics), so it’s important to tell your doctor about all the medications you’re taking.

What Are The Side Effects?

The most common side effects of rexulti include:

Weight Gain weight gain problem

Rexulti (brexpiprazole) is an antipsychotic medication. It works by changing the actions of chemicals in the brain. Weight gain is a common side effect of rexulti. About one in every four people who take rexulti will gain weight.

The average weight gain is about four to six pounds. Some people may gain more weight, and some may gain less. Weight gain is more likely with higher doses of rexulti and may be made worse by diabetes or high cholesterol levels.


Rexulti may lead to changes in sleeping patterns. Depression is often characterized by insomnia, and rexulti may worsen this symptom. As a result, people who take rexulti for depression may find that they wake up feeling tired and unrested. Another possibility is that rexulti can cause an increase in anxiety. Anxiety can be exhausting, both mentally and physically, and it is not uncommon for people with anxiety disorders to experience fatigue.

Finally, rexulti may also cause side effects like dizziness or drowsiness, which can make it difficult to stay awake during the day.


Depression can result in nausea for a variety of reasons. For example, depressed individuals may have a reduced appetite and as a result, may feel nauseous when they try to eat. Additionally, some medications used to treat depression can cause nausea as a side effect.

Finally, research suggests that the brain chemistry of individuals with depression may contribute to feelings of nausea. For example, one study found that people with depression had higher levels of the stress hormone cortisol in their blood compared to people without depression.


There are a few ways that rexulti can cause dizziness. One is by affecting the balance center in the inner ear. This can happen when rexulti changes the level of a chemical called serotonin in the brain. Serotonin is important for many things, including mood and balancing the body’s systems.

Another way rexulti can cause dizziness is by causing low blood pressure. This happens because rexulti slows down the heart rate and reduces the amount of blood pumped through the body. When this happens, there’s not enough blood flowing to the brain and other organs, which can make a person feel lightheaded or dizzy.


Headache is a common side effect of rexulti. It is most likely to occur within the first week of treatment. The exact mechanism by which rexulti causes headache is unknown, but it is thought to be due to the drug’s effect on serotonin levels in the brain. Rexulti increases serotonin activity and too much serotonin can lead to headaches. In most cases, the headaches are mild and go away on their own after a few days.

Dry Mouth

The rexulti for depression results in a dry mouth by reducing the production of saliva. This can be caused by several things, including certain medications, dehydration, and conditions that cause inflammation of the salivary glands. A dry mouth can also be a side effect of rexulti itself.


There are a few different ways that rexulti for depression can cause constipation. One way is by rexulti causing the muscles in the digestive tract to relax. This can lead to slowed movement of food through the digestive system, which can then lead to constipation.

Another way that rexulti can cause constipation is by increasing the amount of water that is absorbed from the stool. This can make the stool harder to pass. Finally, rexulti may also interfere with the body’s natural production of a substance called mucin. Mucin helps to keep the stool soft and easy to pass. Without enough mucin, the stool can become hard and dry, making it more difficult to pass.

Sexual Dysfunction

Sexual dysfunction is a common side effect of rexulti. This can manifest in a variety of ways, including decreased libido, difficulty achieving orgasm, and erectile dysfunction.

The mechanism by which rexulti causes sexual dysfunction is not fully understood, but it is thought to be related to its effects on serotonin levels in the brain. This can further make you feel agitated, anxious, and even more depressed.

What Are The Precautions? precautions

Some important things to keep in mind while taking rexulti for depression:

  • rexulti may increase the risk of suicidal thoughts or behaviors. Be sure to monitor your mood and contact your doctor if you experience any changes.
  • rexulti may cause drowsiness, so be careful when operating heavy machinery or driving.
  • Avoid drinking alcohol while taking rexulti, as it can intensify some of the side effects.
  • Be sure to tell your doctor about any other medications you are taking, as rexulti can interact with some drugs.
  • Don’t take it during your pregnancy or breastfeeding period. Try to take some alternatives available at that time.
  • Always take rexulti exactly as prescribed by your doctor. Do not change your dose or stop taking rexulti without talking to your doctor first.
  • If you miss a dose of rexulti, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue on your regular schedule. Do not take two doses of rexulti at once.
  • You should not stop using rexulti suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medicine. Store at room temperature away from moisture and heat. Do not freeze rexulti oral solution. Throw away any unused rexulti oral solution after 90 days.
  • Keep track of the amount of medicine used from each new bottle. Rexulti is a drug of abuse and you should be aware if anyone is using it improperly or without a prescription.
  • Do not take more rexulti than prescribed by your doctor.


Rexulti is an excellent medication for treating depression. It has very few side effects and it is affordable. If you are thinking about starting rexulti, make sure to consult your doctor first.

Be sure to consult your doctor before starting rexulti to ensure it is the best treatment option for you. Depression is a serious illness, but with the help of rexulti, many people can find relief from their symptoms and live happier healthier lives.

For more information, please contact MantraCare. Depression is a mental illness characterized by persistent feelings of sadness, hopelessness, and loss of interest in daily activities. If you have any queries regarding Online Depression Counseling experienced therapists at MantraCare can help: Book a trial Depression Therapy session

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